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A pathological hallmark of Alzheimer’s disease, an abundance of neuritic plaques in key areas of the brain involved in memory and cognition. Decades of studies have confirmed 42 forms the seed of the amyloid plaques that accumulate gradually in the brain and induce cell death in the underlying brain tissue ventolin inhaler online usa . This toxic molecule by a process which produces a gradual pivot movement enzyme gamma-secretase. 555,ification of gamma-secretase activity for the production of A? 42, with a consequent? Deposits of A 42-seeded plaques would be , for the prevention of Alzheimer’s disease-associated pathology. We are delighted to make public these data on our gamma secretase modulator, NGP 555, said Dr. William T. President and CEO of neurogenetic Pharmaceuticals. Deposition of amyloid plaques can precede dementia by many years, and the progression of plaques to dementia reflects neuronal loss which is irreversible. We believe that stopping is this gradual progression of pathology of AD to dementia a great unmet need, especially given the growth from an aging population and the enormous cost to society for care and hospitalization. Recent advances in the use of A? biomarkers in the cerebrospinal fluid and brain scans should support early diagnosis of AD pathology and allow us to show that NGP prevented 555, that the amyloid pathology. Of beta amyloidwork published in Neuron , the first of these mechanistically and biochemically distinct GSM connections is described, and they provide a selective mechanism than GSIs The key advantages of these small molecules include the reduction of. Toxic form of beta-amyloid shown in transgenic mice AD dose-dependent lowering of plasma and brain A? Chronic daily administration for 7 months can lead to significant reduction in both diffuse and neuritic plaques, without the GI side effects with GSI found connections, according to the paper in Neuron. The work that at at TorreyPines Therapeutics carried out in collaboration with academic institutions, concludes, that these types of GSM compounds warrant further investigation as a potentially safe and effective method for the prevention of AD. This study is is a biomarker and pathology findings with a mechanistic understanding of how involved our compounds selectively on a key enzyme in the pathology of Alzheimer’s disease combines said Maria Z. Kounnas, lead author of the study and vice president of of the Alzheimer’s Research at NGP. can prevent combining of early disease identification with a treatment of AD pathology, such as NGP 555, would be a major step forward in our ability to prevent AD or its progression to dementia. Obviously, the earlier it will be detected AD and treated, the better the likelihood of a good result. .

Neurogenic tables Pharmaceuticals Announces Studies show brought its proprietary compound reduces brain plaques associated with AlzheimerIn the 9th September 2010 issue of Neuron, reported neurogenetic Pharmaceuticals proof of concept studies that show its proprietary compound NGP 555, is effective in preventing the amyloid pathology of Alzheimer ‘s disease in a transgenic mouse model. The study shows that the further chronic treatment with the gamma – secretase modulator compound from NGP, the mice were without gastrointestinal side effects, an adverse finding is usually associated with a gamma-secretase inhibitor .

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